Peptide Graded

Families

GLP-1 drugs and successors

The injections behind Ozempic, Wegovy, Mounjaro and Zepbound, plus the next wave in trials. They copy a gut hormone that slows digestion and cuts appetite. The approved ones have some of the largest trials of any peptide; the newer ones are promising but unapproved.

17 peptides: 10 at A, 7 at B
  1. AAlbiglutideFDA approvedLarge trials: lowered blood sugar, and fewer heart attacks and strokes (7% vs 9% on placebo).
  2. ACagriSemaIn clinical trialsAbout 20% weight loss over 68 weeks versus 3% on placebo. It missed its goal against tirzepatide.
  3. ADulaglutideFDA approvedLarge trials: lower blood sugar; 12% lower risk of heart attack, stroke or heart death in 9,901 people.
  4. AExenatideFDA approvedTrials support it for type 2 diabetes. For weight loss it works only a little.
  5. ALiraglutideFDA approvedIn 3,731 adults it gave about 8% weight loss. In 9,340 patients it cut heart problems.
  6. ALixisenatideFDA approvedIt lowers blood sugar. In 6,068 people it neither helped nor harmed the heart.
  7. AMazdutideIn clinical trialsTwo trials in China: about 15% weight loss more than placebo over 48 to 60 weeks.
  8. APramlintideFDA approvedLowered blood sugar a little (0.25 to 0.34 points) and weight, with nausea and low sugar risk.
  9. ASemaglutideFDA approvedAbout 15% weight loss and 20% fewer major heart events. Weight returns after stopping.
  10. ATirzepatideFDA approvedLarge trials: 15% to 21% weight loss and better blood sugar. Weight returns after stopping.
  11. BAmycretinIn clinical trialsLarge weight loss in early trials of up to 36 weeks, but small trials and many dropouts.
  12. BCagrilintideIn clinical trialsAlone: about 6% to 11% weight loss at 26 weeks. With semaglutide: about 20% at 68 weeks.
  13. BEfpeglenatideIn clinical trialsFewer heart attacks and strokes: 7.0% versus 9.2% on a dummy shot, in 4,076 people.
  14. BPemvidutideIn clinical trialsLiver damage cleared in 52% to 58%, versus 20% on a dummy shot. Scarring did not clearly improve.
  15. BPetrelintideIn clinical trialsAbout a tenth of body weight lost over 42 weeks, with mild nausea, in one trial.
  16. BRetatrutideIn clinical trialsPeople lost up to 24.2% of body weight in 48 weeks, versus 2.1% on a dummy shot.
  17. BSurvodutideIn clinical trialsUp to 16.6% weight loss versus 3.2% on a dummy shot; liver damage cleared more often.

Grades are per compound, for the use it is best known for. How grades work.