Peptide Gradedhttps://peptidegraded.com/2026-10-27T13:00:00ZRefresh 2026-10-27: 10 pages updatedhttps://peptidegraded.com/essays/#refresh-2026-10-272026-10-27T13:00:00Z<ul><li>carnosine: added O&#x27;Toole 2026 RCT of oral carnosine for endurance (n=299, mostly null; PMID 42308284) to human findings and key studies; grade stays C for the skin use.</li><li>daptomycin: added Spanish nationwide prospective cohort of daptomycin vs vancomycin in left-sided MRS endocarditis (n=617, similar mortality, fewer adverse reactions; PMID 42097302) to human findings.</li><li>davunetide: the existing paragraph on the 2026 sex-specific reanalysis of the PSP trial now cites its own paper (PMID 42399413) instead of Boxer 2014, with conflict-of-interest note.</li><li>degarelix: added FAERS interstitial lung disease signal across antiandrogens including degarelix (PMID 42154420) to safety, flagged as exploratory.</li><li>dulaglutide: added DIADEMA RCT, dulaglutide vs insulin in 80 adolescents with thalassaemia-induced diabetes (PMID 42618811) to human findings and key studies.</li><li>liraglutide: added blinded RCT in 18 adults with long-standing type 1 diabetes, no C-peptide preservation and a possible faster decline (PMID 42595732) to human findings and key studies.</li><li>mazdutide: added the published US phase 2 RCT (n=179, up to 18.1% weight loss at 32 weeks, 20% discontinuation at top dose; PMID 42628555); replaced the &quot;ongoing&quot; key-study row, updated FDA statement, reasoning and safety. No FDA filing found.</li><li>pegcetacoplan: safety paragraph on the eye formulation now cites the IRIS Registry endophthalmitis rate (6.6 vs 3.3 per 10,000; PMID 42472569) and FAERS retinal vasculitis reports (PMID 42627260).</li><li>petrelintide: ZUPREME-1 citation switched from DOI to its PubMed record (PMID 42810355); corrected the weight-loss figures (7.9 to 9.8% at 28 weeks, up to 10.7% at 42) and the nausea rate (20% vs 6%), which the page had described as placebo-like.</li><li>tirzepatide: added 23-patient lithium co-prescription series with one symptomatic lithium toxicity (PMID 42803597) to safety.</li></ul>We graded 152 peptideshttps://peptidegraded.com/essays/graded-152/2026-10-27T13:00:00ZWhat a reader learns from putting every peptide on the same evidence scale.