Peptide Graded

AOD-9604

Is AOD-9604 safe?

Only 'well tolerated' claims, unpublished

CAnimal and cell studiesNot approvedas of 2026-10-27

The maker's six trials reported that AOD-9604 was well tolerated. Side effects matched placebo. There was no effect on IGF-1 or on glucose handling, and no anti-drug antibodies were found. This safety summary is the one human finding that was published. 12

The FDA's 2023 review put AOD-9604 in Category 2 for compounding. It cited too little safety information and worries about immune reactions and impurities in peptide products. The nomination was later withdrawn, and in December 2024 an FDA advisory committee voted 12 to 0 against adding it to the list of substances pharmacies may compound. Products sold online are not tested for identity or purity. Anti-doping labs have analysed seized vials. The World Anti-Doping Agency lists AOD-9604 as a banned growth hormone fragment. 4789

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Citations

  1. Heffernan 2001, Hormone Research: lipolytic growth hormone fragment in obese mice doi.org
  2. Heffernan 2001, International Journal of Obesity: AOD9604 in obese mice doi.org
  3. Current Cardiology Reviews 2013: obesity pharmacotherapy, current perspectives and future directions pubmed.ncbi.nlm.nih.gov
  4. Drug Testing and Analysis 2015: detection and in vitro metabolism of AOD9604 pubmed.ncbi.nlm.nih.gov
  5. DailyMed: somatropin label, 191-amino-acid human growth hormone dailymed.nlm.nih.gov
  6. Drug Testing and Analysis 2013: AOD-9604 does not influence the WADA hGH isoform immunoassay pubmed.ncbi.nlm.nih.gov
  7. FDA: bulk drug substances that may present significant safety risks in compounding fda.gov
  8. WADA: 2026 Prohibited List wada-ama.org
  9. FDA: 503A bulk drug substances category list (2023 update) fda.gov
  10. FDA Drugs@FDA: tesamorelin (Egrifta) approval record accessdata.fda.gov
  11. Falutz 2007, NEJM: metabolic effects of tesamorelin in patients with HIV pubmed.ncbi.nlm.nih.gov
  12. Stier 2013, Journal of Endocrinology and Metabolism: safety and tolerability of the hexadecapeptide AOD9604 in humans doi.org

Reference information only, not medical advice. Drawn from the AOD-9604 article, fact-checked against the cited sources. No dosing anywhere on this site.