Peptide Graded

Aviptadil

Is Aviptadil legal in the US?

No. It is not approved and is sold as a research chemical.

BSome human evidenceIn clinical trialsas of 2026-10-26

Aviptadil is not approved by the FDA for any use. The FDA declined requests for emergency use authorisation in critical COVID-19 in 2021 and 2022, and the investigational product has not been approved since. A combination of aviptadil with phentolamine (Invicorp) is approved in the United Kingdom and some other countries as an injection for erectile dysfunction, but not in the United States. 7910

No. The FDA refused emergency use authorisation for critical COVID-19, and no approval has followed. The erectile dysfunction combination Invicorp is approved in the UK and elsewhere, but not in the United States. 7910

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More on Aviptadil

Citations

  1. Said and Mutt 1970, Science: polypeptide with broad biological activity isolated from small intestine pubmed.ncbi.nlm.nih.gov
  2. PMC 2023: independent analysis of aviptadil COVID-19 evidence pmc.ncbi.nlm.nih.gov
  3. PMC 2021: VIP receptors VPAC1 and VPAC2 pmc.ncbi.nlm.nih.gov
  4. Goetzl 2002, Regulatory Peptides: immunoeffector and immunoregulatory activities of VIP pubmed.ncbi.nlm.nih.gov
  5. Couvineau 2012, Br J Pharmacol: VPAC receptor structure and pharmacology pubmed.ncbi.nlm.nih.gov
  6. Amino Acids 2013: VIP, a neuropeptide with pleiotropic immune functions pubmed.ncbi.nlm.nih.gov
  7. The Pharma Letter: FDA declines EUA for aviptadil in critical COVID-19 thepharmaletter.com
  8. GlobeNewswire 2020: Fast Track designation for RLF-100 (aviptadil) globenewswire.com
  9. NRx Pharmaceuticals 10-Q, Q1 2022: FDA declined emergency use request sec.gov
  10. All Wales Therapeutics and Toxicology Centre: aviptadil/phentolamine (Invicorp) recommendation awttc.nhs.wales
  11. ACTIV-3b/TESICO 2023, Lancet Respiratory Medicine: aviptadil and remdesivir for COVID-19 respiratory failure doi.org

Reference information only, not medical advice. Drawn from the Aviptadil article, fact-checked against the cited sources. No dosing anywhere on this site.