Is Cetrorelix safe?
Label data, decades of use
AStrong human evidenceFDA approvedas of 2026-10-26
The most common effects on the label are injection-site reactions such as redness, itching and swelling. Nausea and headache also occur. Ovarian hyperstimulation syndrome can still occur, because the FSH stimulation drives it. The Cochrane review found it less often with antagonist protocols. Allergic reactions including anaphylaxis have been reported. The drug must not be used in pregnancy. 14
Long-term safety data on children born from antagonist cycles have shown no warning signs. But the review says this outcome is reported less often than live birth. 4
More on Cetrorelix
Citations
- FDA label, 2023: Cetrotide (cetrorelix acetate for injection) accessdata.fda.gov
- DrugBank DB00050: cetrorelix go.drugbank.com
- Olivennes 2000, Fertil Steril: single-dose cetrorelix in controlled ovarian stimulation doi.org
- Al-Inany 2016, Cochrane: GnRH antagonists for assisted reproductive technology doi.org
Reference information only, not medical advice. Drawn from the Cetrorelix article, fact-checked against the cited sources. No dosing anywhere on this site.