Is Davunetide safe?
Serious events equal across arms in 52 weeks
In the 52-week trial, davunetide was well tolerated. Each arm had 54 serious adverse events. There were 11 deaths on davunetide and 10 on placebo, which fits the underlying disease. Nasal irritation was the main complaint tied to the drug. Earlier phase 1 and 2 studies in healthy volunteers and people with mild cognitive impairment reported no safety signals. 2
The unknowns concern products sold online. No one knows their purity. There are also no human data for the memory or autism uses they are marketed for. 1
In the trial it was as well tolerated as placebo over a year. Nasal irritation was the main complaint. That says nothing about research-chemical vials of unknown purity. 2
More on Davunetide
Citations
- Gozes 2011, Curr Pharm Des: davunetide (NAP) and microtubules, review doi.org
- Boxer 2014, Lancet Neurol: davunetide in patients with progressive supranuclear palsy, randomised double-blind placebo-controlled trial doi.org
- Shapira 2026, Mol Psychiatry: sex-specific reanalysis of the davunetide PSP trial pubmed.ncbi.nlm.nih.gov
Reference information only, not medical advice. Drawn from the Davunetide article, fact-checked against the cited sources. No dosing anywhere on this site.