Is Goserelin safe?
Decades of label and trial data
AStrong human evidenceFDA approvedas of 2026-10-26
The common side effects come from hormone suppression. These are hot flushes, loss of libido and mood changes. Men can have erectile dysfunction. Women can have vaginal dryness. With long use, bone mineral loss can occur. The first flare can worsen bone pain or urinary blockage in men with metastatic prostate cancer. So doctors sometimes add an anti-androgen. The label also warns about high blood sugar and QT prolongation. It warns of heart risk in men on androgen deprivation. Doctors must rule out pregnancy first in women. 2
More on Goserelin
Citations
- Kaufmann 2003, European Journal of Cancer: survival analyses from the ZEBRA study, goserelin versus CMF in premenopausal node-positive breast cancer doi.org
- FDA 2026: Zoladex (goserelin implant) prescribing information accessdata.fda.gov
Reference information only, not medical advice. Drawn from the Goserelin article, fact-checked against the cited sources. No dosing anywhere on this site.