Is MK-677 (ibutamoren) safe?
Glucose rise seen in controlled trials
In the older-adult trial, the common side effects were increased appetite (which faded over months), brief mild leg swelling and muscle pain. The main concern is the metabolic findings. Fasting glucose rose and insulin sensitivity decreased. That matters for anyone at risk of diabetes. The 563-patient Alzheimer's trial found the drug generally tolerated over a year. 45
The FDA's Category 2 designation reflects the lack of long-term safety data and the metabolic signal. No one has studied years of use in young healthy people, who are the actual customer base. Online products have no quality assurance. 15
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Citations
- FDA: Bulk drug substances nominated for use in compounding under section 503A, category list fda.gov
- Nass 2008, Ann Intern Med: Effects of an oral ghrelin mimetic on body composition in healthy older adults (DOI) doi.org
- Sevigny 2008, Neurology: MK-677 no clinical effect on AD progression (DOI) doi.org
- Sevigny 2008, Neurology: Growth hormone secretagogue MK-677, no clinical effect on AD progression pubmed.ncbi.nlm.nih.gov
- Nass 2008, Ann Intern Med: Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults pubmed.ncbi.nlm.nih.gov
Reference information only, not medical advice. Drawn from the MK-677 (ibutamoren) article, fact-checked against the cited sources. No dosing anywhere on this site.