Is Nafarelin safe?
Label data and trial adverse events
The common side effects are those of low estrogen. They are hot flashes, vaginal dryness, reduced libido, headaches, mood swings and acne. Nasal irritation is specific to the spray. The main concern with longer use is loss of bone mineral density. That is why the label limits the length of an endometriosis course. It also warns against repeat courses without a specific reason. Nafarelin can cause harm in pregnancy. The label requires that pregnancy be ruled out before starting. 23
Hormones flare up in the first weeks, before suppression sets in. This can temporarily worsen symptoms. In children it can show as a brief increase in signs of puberty. 23
More on Nafarelin
Citations
- Henzl 1988, N Engl J Med: nasal nafarelin compared with oral danazol for endometriosis pubmed.ncbi.nlm.nih.gov
- Pfizer: Synarel (nafarelin) prescribing information pfizermedical.com
- Pfizer: Synarel adverse reactions pfizermedical.com
Reference information only, not medical advice. Drawn from the Nafarelin article, fact-checked against the cited sources. No dosing anywhere on this site.