Is Parathyroid hormone legal in the US?
No. It was approved in 2015 for low calcium from underactive parathyroid glands, but it is being discontinued worldwide.
AStrong human evidenceFDA approvedas of 2026-10-26
Recombinant parathyroid hormone was approved in 2015 as Natpara for hypocalcemia in hypoparathyroidism that cannot be controlled with calcium and active vitamin D alone, with a boxed warning for osteosarcoma and a restricted distribution program. Takeda recalled it in the United States in 2019 over particles from the cartridge septum and announced in 2022 that manufacturing would end globally at the end of 2024. 12
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Citations
- Mannstadt 2013, Lancet Diabetes Endocrinol: efficacy and safety of recombinant human parathyroid hormone (1-84) in hypoparathyroidism (REPLACE) doi.org
- Takeda 2022: statement on discontinuing manufacturing of Natpar/Natpara at the end of 2024 takeda.com
Reference information only, not medical advice. Drawn from the Parathyroid hormone article, fact-checked against the cited sources. No dosing anywhere on this site.