Is PN-943 safe?
Press release data; 12 weeks only
CAnimal and cell studiesIn clinical trialsas of 2026-10-27
In the phase 2 trial, adverse events were described as balanced between PN-943 and placebo. The sponsor's summary reported no serious safety signal. The peptide is barely absorbed. So side effects in the body were expected to be few. Only 159 patients were treated, for 12 weeks. The full trial has no peer-reviewed publication. So the safety picture is thin. It rests on a press release and a conference presentation. 2
More on PN-943
Citations
- Sandborn 2021, Gastroenterology: PTG-100, an oral alpha4beta7 antagonist peptide, preclinical development and phase 1 and 2a studies in ulcerative colitis doi.org
- HCPLive 2022: phase 2 IDEAL trial results for PN-943 in ulcerative colitis hcplive.com
- BioSpace: Protagonist third quarter 2022 results and corporate update biospace.com
Reference information only, not medical advice. Drawn from the PN-943 article, fact-checked against the cited sources. No dosing anywhere on this site.