Peptide Graded

Tesamorelin

Is Tesamorelin legal in the US?

Yes, FDA approved for belly fat in adults with HIV.

BSome human evidenceFDA approvedas of 2026-10-26

Tesamorelin is approved by the FDA as Egrifta (2010), Egrifta SV, and Egrifta WR (2025) to reduce excess abdominal fat in adults with HIV and lipodystrophy. It is not approved for weight loss, fat loss in people without HIV, or anti-aging. 136

Reducing extra belly fat in adults with HIV who have lipodystrophy. That is the only FDA-approved use across all three Egrifta forms. Using it for weight loss or body composition in people without HIV is off-label. 16

Read the full Tesamorelin page

More on Tesamorelin

Citations

  1. DailyMed: Egrifta (tesamorelin) prescribing information dailymed.nlm.nih.gov
  2. Falutz 2010, JAIDS: Tesamorelin in HIV-infected patients with abdominal fat accumulation, randomized trial with safety extension doi.org
  3. DailyMed: Egrifta WR (tesamorelin) prescribing information dailymed.nlm.nih.gov
  4. Falutz 2008, AIDS: Long-term safety and effects of tesamorelin, 52-week extension doi.org
  5. Falutz 2010, JAIDS: Effects on visceral adipose tissue doi.org
  6. FDA 2025: Egrifta prescribing information (NDA 022505) accessdata.fda.gov
  7. Stanley 2012, J Clin Endocrinol Metab: Metabolic effects of a GHRH analog in obese subjects with reduced GH secretion, randomized controlled trial pubmed.ncbi.nlm.nih.gov
  8. Stanley 2019, Lancet HIV: Effects of tesamorelin on non-alcoholic fatty liver disease in HIV, randomized trial pubmed.ncbi.nlm.nih.gov
  9. Falutz 2007, NEJM: Metabolic effects of a growth hormone-releasing factor in patients with HIV pubmed.ncbi.nlm.nih.gov
  10. Falutz 2010, J Clin Endocrinol Metab: Pooled analysis of two phase 3 tesamorelin trials pubmed.ncbi.nlm.nih.gov
  11. Falutz 2010, JAIDS: Tesamorelin in HIV with abdominal fat, randomized trial with safety extension pubmed.ncbi.nlm.nih.gov
  12. Clemmons 2017, PLoS One: Safety and metabolic effects of tesamorelin in type 2 diabetes, randomized trial pubmed.ncbi.nlm.nih.gov
  13. DailyMed: Egrifta label, warnings on glucose dailymed.nlm.nih.gov
  14. Ferdinandi 2007, Basic Clin Pharmacol Toxicol: Non-clinical pharmacology and safety of TH9507 pubmed.ncbi.nlm.nih.gov

Reference information only, not medical advice. Drawn from the Tesamorelin article, fact-checked against the cited sources. No dosing anywhere on this site.