Peptide Graded

Ziconotide

Is Ziconotide legal in the US?

Yes, FDA approved for severe long-term pain, given by a spinal pump.

AStrong human evidenceFDA approvedas of 2026-10-26

Ziconotide is approved by the FDA as Prialt (December 2004) for the management of severe chronic pain in patients for whom intrathecal therapy is warranted and who are intolerant of or refractory to other treatments. It is delivered by an implanted pump into the fluid around the spinal cord and carries a boxed warning for severe psychiatric symptoms and neurological impairment. 2

Yes, as Prialt since December 2004. It is for severe chronic pain. Patients must need intrathecal therapy. They must also have not tolerated or responded to other treatments. It is approved only for delivery into the spinal fluid by implanted pump. 2

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More on Ziconotide

Citations

  1. Staats 2004, JAMA: Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS, randomized controlled trial doi.org
  2. Prialt (ziconotide intrathecal infusion) prescribing information drugs.com

Reference information only, not medical advice. Drawn from the Ziconotide article, fact-checked against the cited sources. No dosing anywhere on this site.