Peptide Graded

Dihexa

Does Dihexa work?

No. It has only been tried in rodents and cells, and no human trial exists.

CAnimal and cell studiesNot approvedas of 2026-10-27

The evidence for the use dihexa is sold for, memory and cognition, consists of rat and mouse behavioral studies and cell culture work. No human trial exists and none is registered. 581011 Two of the foundational papers from the originating laboratory were retracted in April 2025 and the third carries an expression of concern, so even the animal literature is weaker than it looks. 678

There are no published human studies of dihexa, controlled or otherwise. 10

Evidence checklist

  • Randomised controlled trial No human trial exists
  • Human study over 100 people No human studies
  • More than one research group Key papers retracted, same laboratory
  • Clinical outcomes, not surrogate markers Rodent behavior tests only
  • Human safety data beyond case reports No human safety data

Read the full Dihexa page

More on Dihexa

Citations

  1. McCoy 2013, J Pharmacol Exp Ther: metabolically stabilized angiotensin IV analogs as procognitive agents (DOI record) doi.org
  2. Benoist 2014, J Pharmacol Exp Ther: procognitive effects dependent on HGF/c-Met (retracted) doi.org
  3. JAAOS Global Research & Reviews 2025: review of peptides in orthopaedic practice doi.org
  4. FDA: certain bulk drug substances for use in compounding that may present significant safety risks fda.gov
  5. Benoist 2012, J Pharmacol Exp Ther: angiotensin IV analogs as HGF/Met modifiers (retracted 2025) pmc.ncbi.nlm.nih.gov
  6. Retraction notice 2025, J Pharmacol Exp Ther: Development of angiotensin IV analogs as HGF/Met modifiers pubmed.ncbi.nlm.nih.gov
  7. Retraction notice 2025, J Pharmacol Exp Ther: procognitive effects dependent on HGF/c-Met pubmed.ncbi.nlm.nih.gov
  8. McCoy 2013, J Pharmacol Exp Ther: metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents pubmed.ncbi.nlm.nih.gov
  9. Review 2018, Int J Mol Sci: extracellular matrix and HGF/c-MET signaling in cancer progression pubmed.ncbi.nlm.nih.gov
  10. ClinicalTrials.gov search: dihexa (no registered trials) clinicaltrials.gov
  11. 2021, Brain Sciences: dihexa rescues cognitive impairment in APP/PS1 mice via PI3K/AKT pubmed.ncbi.nlm.nih.gov

Reference information only, not medical advice. Drawn from the Dihexa article, fact-checked against the cited sources. No dosing anywhere on this site.