Peptide Graded

Dihexa

Is Dihexa legal in the US?

No. It is not approved and is sold as a research chemical.

CAnimal and cell studiesNot approvedas of 2026-10-27

Not approved by the FDA for any use and sold as a research chemical. In September 2023 the FDA placed dihexa acetate in Category 2 of bulk substances that may present significant safety risks for compounding, citing the absence of any human exposure data. The FDA now lists it among substances whose nominations were withdrawn, which takes it out of Category 2 but does not approve it or make it eligible for compounding.

No. It is not approved for any use. The FDA added dihexa acetate to its Category 2 compounding list in 2023. It had found safety concerns and no human data. The FDA now lists it among substances whose nominations were withdrawn, which takes it out of Category 2. That does not approve it or make it eligible for compounding. 4

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More on Dihexa

Citations

  1. McCoy 2013, J Pharmacol Exp Ther: metabolically stabilized angiotensin IV analogs as procognitive agents (DOI record) doi.org
  2. Benoist 2014, J Pharmacol Exp Ther: procognitive effects dependent on HGF/c-Met (retracted) doi.org
  3. JAAOS Global Research & Reviews 2025: review of peptides in orthopaedic practice doi.org
  4. FDA: certain bulk drug substances for use in compounding that may present significant safety risks fda.gov
  5. Benoist 2012, J Pharmacol Exp Ther: angiotensin IV analogs as HGF/Met modifiers (retracted 2025) pmc.ncbi.nlm.nih.gov
  6. Retraction notice 2025, J Pharmacol Exp Ther: Development of angiotensin IV analogs as HGF/Met modifiers pubmed.ncbi.nlm.nih.gov
  7. Retraction notice 2025, J Pharmacol Exp Ther: procognitive effects dependent on HGF/c-Met pubmed.ncbi.nlm.nih.gov
  8. McCoy 2013, J Pharmacol Exp Ther: metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents pubmed.ncbi.nlm.nih.gov
  9. Review 2018, Int J Mol Sci: extracellular matrix and HGF/c-MET signaling in cancer progression pubmed.ncbi.nlm.nih.gov
  10. ClinicalTrials.gov search: dihexa (no registered trials) clinicaltrials.gov
  11. 2021, Brain Sciences: dihexa rescues cognitive impairment in APP/PS1 mice via PI3K/AKT pubmed.ncbi.nlm.nih.gov

Reference information only, not medical advice. Drawn from the Dihexa article, fact-checked against the cited sources. No dosing anywhere on this site.