Does Palmitoyl tripeptide-1 work?
No meaningful testing published.
The peer-reviewed record identified is a 2018 industry safety assessment covering toxicity, not benefit. Efficacy claims come from the manufacturer's testing of the Matrixyl 3000 blend, in which this peptide is combined with palmitoyl tetrapeptide-7, and have not been published in a form that isolates it. No independent human trial exists in these sources. 1
We have not found a published controlled trial of palmitoyl tripeptide-1 alone in people. The clinical results quoted for Matrixyl 3000 come from the maker's own tests of the two-peptide blend. They include less wrinkle depth and roughness over two months. Published studies that include the blend test it inside finished products with many ingredients. Those studies cannot tell you what this peptide adds. 1
Evidence checklist
- Randomised controlled trial No peer-reviewed efficacy trial
- Human study over 100 people No human efficacy study
- More than one research group Efficacy claims from the maker only
- Clinical outcomes, not surrogate markers No clinical outcome
- Human safety data beyond case reports 2018 CIR review found it safe in cosmetics
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More on Palmitoyl tripeptide-1
Citations
- Cosmetic Ingredient Review 2018, Int J Toxicol: safety assessment of tripeptide-1, hexapeptide-12, their metal salts and fatty acyl derivatives, and palmitoyl tetrapeptide-7 pure.psu.edu
- FDA: how cosmetics are not FDA-approved but are FDA-regulated fda.gov
Reference information only, not medical advice. Drawn from the Palmitoyl tripeptide-1 article, fact-checked against the cited sources. No dosing anywhere on this site.