Does Tripeptide-10 citrulline work?
No meaningful testing published: one paper from the maker, with no human trial.
The entire published record is one 2008 paper by scientists at the ingredient's manufacturer, Lipotec, describing an in vitro collagen-assembly assay and stating that the peptide increases skin suppleness, without a reported human sample size or control group. There is no independent replication and no controlled trial with clinical endpoints, so the firming and anti-wrinkle claims grade D. 1
A 2008 paper in the International Journal of Cosmetic Science describes its in vitro results. It ends with the statement that the peptide increases skin suppleness. But its summary gives no human sample size, duration or control group. The authors were Lipotec employees. No independent group has published a human test. 1
Evidence checklist
- Randomised controlled trial One placebo-controlled volunteer study
- Human study over 100 people About two dozen treated subjects
- More than one research group Single manufacturer paper
- Clinical outcomes, not surrogate markers Skin suppleness, not clinical
- Human safety data beyond case reports Little safety data
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Citations
- Puig 2008, Int J Cosmet Sci: A new decorin-like tetrapeptide for optimal organization of collagen fibres doi.org
Reference information only, not medical advice. Drawn from the Tripeptide-10 citrulline article, fact-checked against the cited sources. No dosing anywhere on this site.