Is Histrelin safe?
Label data; implant-site problems
BSome human evidenceFDA approvedas of 2026-10-26
The most common problems are at the implant site. They include bruising, pain and swelling. Sometimes the implant breaks during removal, and that can need a second cut. In the first weeks, sex hormones briefly rise. This can cause a short episode of vaginal bleeding in girls. The label notes that seizures have been reported with this drug class, mostly in children with other risk factors. It also says to consider bone density with long use. The drug leaves the body when the implant comes out, so the effects are reversible. 2
More on Histrelin
Citations
- Eugster 2007, Journal of Clinical Endocrinology and Metabolism: histrelin subdermal implant in children with central precocious puberty, 12-month results doi.org
- Endo: Supprelin LA (histrelin acetate) prescribing information endodocuments.com
- MDedge/KHN: patients lose cheaper option as Vantas is discontinued mdedge.com
Reference information only, not medical advice. Drawn from the Histrelin article, fact-checked against the cited sources. No dosing anywhere on this site.