Peptide Graded

Humanin

Is Humanin legal in the US?

No. It is not approved and is sold as a research chemical.

CAnimal and cell studiesNot approvedas of 2026-10-27

Humanin is not approved by the FDA for any use and is sold online as a research chemical. It is not a controlled substance under the DEA schedules. It does not appear in any of the FDA's three categories of substances nominated for compounding under section 503A, so the FDA's interim compounding policy does not cover it.

No. No one has ever submitted humanin for approval. It has no approved use. Online products are sold as research chemicals. Approved peptides such as bremelanotide and tesamorelin went through trials and carry FDA labels. 1213

The DEA does not list it as a controlled substance. So having it is not a drug offence. Selling it for human use without approval is a different matter. The FDA treats unapproved peptides sold for injection as unapproved drugs. Humanin does not appear in any of the FDA's three categories of substances nominated for compounding, so the FDA's interim compounding policy does not cover it. 41011

Read the full Humanin page

More on Humanin

Citations

  1. Muzumdar 2009, PLoS One: humanin as a central regulator of peripheral insulin action doi.org
  2. Zarate 2019, Frontiers in Aging Neuroscience: humanin released by astrocytes prevents synapse loss in hippocampal neurons doi.org
  3. Yen 2020, Aging: the mitochondrial derived peptide humanin is a regulator of lifespan and healthspan doi.org
  4. DEA: controlled substances alphabetical list (Orange Book) deadiversion.usdoj.gov
  5. Journal of Clinical Investigation 2022: mitochondria-derived peptides in aging and healthspan, review pubmed.ncbi.nlm.nih.gov
  6. Conte 2019, Journals of Gerontology A: human aging and longevity are characterised by high levels of mitokines pubmed.ncbi.nlm.nih.gov
  7. GeroScience 2021: disease-specific plasma levels of FGF21, GDF15 and humanin in diabetes and Alzheimer's disease pubmed.ncbi.nlm.nih.gov
  8. Yen 2018, Scientific Reports: humanin prevents age-related cognitive decline in mice and is associated with cognitive age in humans pubmed.ncbi.nlm.nih.gov
  9. International Journal of Biological Macromolecules 2011: biological activity of humanin analogs correlates with structure stability pubmed.ncbi.nlm.nih.gov
  10. FDA: certain bulk drug substances for use in compounding may present significant safety risks fda.gov
  11. FDA: bulk drug substances nominated for use in compounding under section 503A, category list fda.gov
  12. FDA Drugs@FDA: bremelanotide (Vyleesi) application 210557 accessdata.fda.gov
  13. FDA Drugs@FDA: tesamorelin (Egrifta) application 022505 accessdata.fda.gov

Reference information only, not medical advice. Drawn from the Humanin article, fact-checked against the cited sources. No dosing anywhere on this site.