Peptide Graded

Humanin

Is Humanin safe?

Never given to humans in a published study

CAnimal and cell studiesNot approvedas of 2026-10-27

No human has received humanin or its lab-made versions in a published clinical study. So there are no human safety data. High humanin goes with worse metabolic measures in older adults. This is a caution against assuming more is better. Products sold online as humanin or HNG are untested for identity, purity or sterility. 65

Read the full Humanin page

More on Humanin

Citations

  1. Muzumdar 2009, PLoS One: humanin as a central regulator of peripheral insulin action doi.org
  2. Zarate 2019, Frontiers in Aging Neuroscience: humanin released by astrocytes prevents synapse loss in hippocampal neurons doi.org
  3. Yen 2020, Aging: the mitochondrial derived peptide humanin is a regulator of lifespan and healthspan doi.org
  4. DEA: controlled substances alphabetical list (Orange Book) deadiversion.usdoj.gov
  5. Journal of Clinical Investigation 2022: mitochondria-derived peptides in aging and healthspan, review pubmed.ncbi.nlm.nih.gov
  6. Conte 2019, Journals of Gerontology A: human aging and longevity are characterised by high levels of mitokines pubmed.ncbi.nlm.nih.gov
  7. GeroScience 2021: disease-specific plasma levels of FGF21, GDF15 and humanin in diabetes and Alzheimer's disease pubmed.ncbi.nlm.nih.gov
  8. Yen 2018, Scientific Reports: humanin prevents age-related cognitive decline in mice and is associated with cognitive age in humans pubmed.ncbi.nlm.nih.gov
  9. International Journal of Biological Macromolecules 2011: biological activity of humanin analogs correlates with structure stability pubmed.ncbi.nlm.nih.gov
  10. FDA: certain bulk drug substances for use in compounding may present significant safety risks fda.gov
  11. FDA: bulk drug substances nominated for use in compounding under section 503A, category list fda.gov
  12. FDA Drugs@FDA: bremelanotide (Vyleesi) application 210557 accessdata.fda.gov
  13. FDA Drugs@FDA: tesamorelin (Egrifta) application 022505 accessdata.fda.gov

Reference information only, not medical advice. Drawn from the Humanin article, fact-checked against the cited sources. No dosing anywhere on this site.