Is Pentapeptide-18 safe?
No formal safety study
CAnimal and cell studiesCosmetic ingredientas of 2026-10-26
The 2014 study reported no side effects in its 20 volunteers. The 2024 study reported that the nanoparticle form reduced the irritation retinol usually causes. Cosmetic peptides of this type are used at low concentrations. But no formal safety study of pentapeptide-18 alone exists. Two short studies of 20 people cannot detect uncommon reactions. 13
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Citations
- Dragomirescu 2014, Cosmetics (MDPI): the efficiency and safety of Leuphasyl, a botox-like peptide mdpi.com
- SpecialChem: Lubrizol Leuphasyl (pentapeptide-18) product listing specialchem.com
- Pawłowska 2024, Life: retinol and pentapeptide-18 loaded lipid nanocarriers in anti-acne and anti-aging creams doi.org
Reference information only, not medical advice. Drawn from the Pentapeptide-18 article, fact-checked against the cited sources. No dosing anywhere on this site.