Is Daptomycin legal in the US?
Yes, FDA approved for serious skin infections and staph blood infections.
AStrong human evidenceFDA approvedas of 2026-10-27
Daptomycin is FDA-approved as Cubicin (2003) and generics for complicated skin and skin-structure infections caused by susceptible Gram-positive bacteria and for Staphylococcus aureus bloodstream infections, including right-sided infective endocarditis. It is not approved for pneumonia. 2
Yes. Cubicin was approved in 2003 for complicated skin infections. It was later approved for S. aureus bloodstream infections, including right-sided endocarditis. Generics are available. 2
More on Daptomycin
Citations
- Fowler 2006, NEJM: daptomycin versus standard therapy for bacteremia and endocarditis caused by S. aureus doi.org
- Cubicin (daptomycin for injection) prescribing information merck.com
- Calderón-Parra 2026, Clin Microbiol Infect: daptomycin versus vancomycin in methicillin-resistant staphylococcal left-sided endocarditis, nationwide prospective cohort pubmed.ncbi.nlm.nih.gov
Reference information only, not medical advice. Drawn from the Daptomycin article, fact-checked against the cited sources. No dosing anywhere on this site.