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Plecanatide

Is Plecanatide legal in the US?

Yes, FDA approved for long-lasting constipation and IBS with constipation in adults.

AStrong human evidenceFDA approvedas of 2026-10-26

Plecanatide is FDA-approved as Trulance for adults with chronic idiopathic constipation (January 2017) and irritable bowel syndrome with constipation (2018). The label carries a boxed warning about serious dehydration in children; it is contraindicated under age 6 and not recommended under 18. 2

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Citations

  1. Miner 2017, Am J Gastroenterol: phase 3 trial of plecanatide in chronic idiopathic constipation doi.org
  2. Trulance (plecanatide) prescribing information drugs.com

Reference information only, not medical advice. Drawn from the Plecanatide article, fact-checked against the cited sources. No dosing anywhere on this site.