Plecanatide

Is Plecanatide safe?

Diarrhea rates; pediatric dehydration warning

Diarrhea is the main side effect. About 6 percent of patients in the constipation trial reported it, against 1.3 percent on placebo. A small number stopped treatment because of it. The boxed warning in children is about serious dehydration from severe diarrhea. In young juvenile mice, the drug caused deaths from dehydration. So the label forbids use under age 6 and advises against it under 18. So little reaches the bloodstream that drug interactions are not expected. Long-term safety data beyond the trial extensions are limited. ¹²

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Reference information only, not medical advice. Drawn from the Plecanatide article, fact-checked against the cited sources. No dosing anywhere on this site.